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ASPP基因家族与肿瘤的研究进展 被引量：4

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摘要 细胞凋亡功能异常引起的细胞增殖和死亡失衡是肿瘤形成和发展的重要因素之一。p53是目前公认的与肿瘤发生发展相关性最高的抑癌基因之一，当细胞DNA受到损伤后．受损细胞进入周期停滞或凋亡通路，这一过程主要受p53基因的调控，但p53如何作用于这两种不同的选择机制尚不清楚。
作者 胡红艳 魏万里
机构地区 昆明医学院第三附属医院病理科
出处 《实用医学杂志》 CAS 北大核心 2009年第15期2593-2595,共3页 The Journal of Practical Medicine
基金 云南省应用基础研究面上项目资助(编号:2008ZC140M) 昆明医学院研究生创新基金项目资助(编号:KM2008J09)
关键词 肿瘤形成 基因家族 ASPP P53基因 细胞增殖 功能异常 细胞凋亡 抑癌基因
分类号 R730.2 [医药卫生—肿瘤] R979.1 [医药卫生—药品]
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  • 2Bergamaschi D, Samuels Y, O'Neil N J, et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to hmnan. Nat Genet, 2003,33:162.
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  • 6Yuzhi Chen,Wenyun Liu,Louie Naumovski, et al. ASPP2 inhibits APP-BPl-mediated NEDD8 conjugation to cullin-I and decrease APP-BPI-induced cell proliferation and neuronal apoptosis, Neurochem, 2003,85:801.
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同被引文献57

  • 1陈坤,舒国通,马新源,郑树.肠息肉与结直肠癌发病关系队列研究[J].中国公共卫生,2004,20(2):168-170. 被引量：15
  • 2陈燕平,刘泽军.ASPP蛋白家族在肿瘤细胞凋亡中的作用[J].癌变．畸变．突变,2006,18(6):488-490. 被引量：4
  • 3方赞熙,黄如欣,张忠英.p53凋亡刺激蛋白抑制因子的研究进展[J].医学综述,2007,13(9):661-662. 被引量：5
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实用医学杂志
2009年 第15期

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