复合营养素减肥及调节血脂作用

Effects of multinutrients supplementation on body weight and serum lipids in rats

目的探讨复合营养素(复合维生素、多种矿物质、几丁聚糖)对肥胖大鼠体重及高脂血症大鼠血脂的影响。方法利用高营养饲料、高脂饲料分别诱导大鼠肥胖模型和高脂血症模型后,每种模型分为模型对照组和复合营养素低、中、高剂量组,剂量分别为0.54,1.07,3.21g/(kg.bw),观察复合营养素对大鼠体重及血脂的影响。结果给予复合营养素45d后,复合营养素低、中、高剂量组大鼠体重分别为(469.10±29.75),(475.10±39.69),(467.85±28.79)g,均明显低于肥胖模型组的(505.65±14.34)g(P<0.05);但各组大鼠之间总摄食量比较差异无统计学意义;高脂模型大鼠中复合营养素低、中、高剂量组大鼠血清总胆固醇(TC)分别为(2.67±0.38),(2.51±0.21),(2.79±0.33)mmol/L,均明显低于高脂模型组的(3.10±0.46)mmol/L;甘油三酯(TG)分别为(1.46±0.23),(1.39±0.26),(1.48±0.15)mmol/L,均明显低于高脂模型组的(1.69±0.21)mmol/L;低密度脂蛋白胆固醇(LDL-C)分别为(0.85±0.16),(0.79±0.14),(0.93±0.13)mmol/L,均明显低于高脂模型组的(1.97±0.30)mmol/L;而血清高密度脂蛋白胆固醇(HDL-C)分别为(1.28±0.26),(1.41±0.31),(1.36±0.24)mmol/L,均明显高于高脂模型组的(0.89±0.22)mmol/L(P<0.05)。结论复合营养素对高营养饲料及高脂饲料分别诱导的肥胖大鼠和高脂血症大鼠有减轻体重和调节血脂的作用。

Objective To explore the effects of multinutrient on body weight and serum lipids in diet-induced obese and hyperlipemia rats. Methods Multinutfients were administered to high calorie diet-induced obese and hyperlipidemia rats, which were randomly divided into three dose groups and a base model group. The obesity status were determined, the levels of serum lipids were assessed by enzymatic method. Results Compared with the obese group, there were significant decreases in body-weight, fat mass and food utilization ratio in multinutrients-treated groups（ P 〈 0. 05）. The rats in the three multinutrients dose group did not show significant difference in food intake （ P 〉 0. 05 ）. Compared with hyperlipidemia group, the levels of triglyceride, total cholesterol and low density lipoprotein cholesterol were significantly decreased in the multinutrients-treated groups （ P 〈 0.05 ）, and the serum concentration of high density lipoprotein cholesterol was remarkably increased in the multinutrients-treated groups （ P 〈0. 05 ）. Conclusion Multinutrients are effective for decreasing body weight in obese rats and improving the serum lipids in hyperlipidemia rats.