1585例药品不良反应的费用测算和分析

Calculation and Analysis of Costs of 1585 Cases of Adverse Drug Reactions

目的:测算不同程度药品不良反应(ADR)造成的相关费用并进行比较分析。方法:采用回顾性方式,将收集的ADR病例统计筛选后分为A组(严重组)、B组(治愈组)及C组(自愈组),利用项目法和人力资本法分别测算三组病例由ADR造成的直接和间接费用,忽略隐性成本。结果:A组病例医保支付比例为30.94%,导致住院治疗时间平均11.3d,平均每例需要支付直接费用6,923.78元;B组病例医保支付比例为43.17%,平均每例需要支付直接费用83.75元;C组病例医保支付比例为20.00%,平均每例需要支付直接费用38.81元。敏感性分析提示,药品降价有助于减轻由ADR造成的直接经济损失。结论:ADR造成的费用(特别是严重病例)不容忽视,开展经济学研究应该是ADR监测工作的重点之一。

Objective： To calculate and analyze the costs of different adverse drug reactions （ADR）. Method： The case reports collected in a retrospective way were divided into Group A （serious group）, Group B （healed group） and Group C （naturally cured group）. The direct and indirect costs of the three groups induced by ADR were calculated through item and human capital methods, and then the recessive costs were ignored. Result： The percentages of medical in- surance spent were 30：94% for Group A, 43.17% for Group B and 20.00% for Group C. The average charges of direct costs were 6,923.78 RMB for Group A, 83.75 RMB for Group B and 38.81 RMB for Group C. The average time of hospitalization was 11.3d for Group A. Also, the sensitive analysis hinted that the reduction of drug prices was benefit to ease the direct losses caused by ADR. Conclusion： The costs of ADR should not be neglected, especially in some serious cases. The research of economics was one of of the ADR monitoring key jobs.