茶碱沙丁胺醇缓释片对变应性哮喘作用的研究

Study on the Effects of Theophylline Salbutamol Sustainedrelease Tablets on the Allergic Asthma

茶碱和沙丁胺醇伍用对卵蛋白致敏豚鼠离体气管平滑肌、肺条在抗原攻击时引起的收缩反应，均有明显抑制作用．ＩＣ５０分别为９２～２３０μｇｍＬ－１和５９～２２９μｇ·ｍＬ１．茶碱／沙丁胺醇３种剂量（１２０ｍｇ／０１６ｍｇ·ｋｇ－１，２４０ｍｇ／０３２ｍｇ·ｋｇ－１，４８０ｍｇ／０６４ｍｇ·ｋｇ－１）灌胃给药明显延长过敏性哮喘豚鼠引喘潜伏期及减少致敏麻醉豚鼠的肺溢流量增加．

Combined theophylline and salbutamol markedly inhibited anaphylactic contraction indused by antigen challenged in exsomatize trachea smooth muscle(I) and lung stripes(Ⅱ) of guineapigs sensitized by obalbumin.IC50 of (I) was 9.0～23.0μg/mL ,IC50 of (Ⅱ)was 5.9～22.9μg/mL.Theophylline/Salbutomal=12.0mg/kg,24.0mg/0.32mg/kg,48.0/0.6mg/kg ig.postponed the sensitized guineapig asthamogenic latency and reduced anesthetic guinapig pulmooverflow.