红霉素抗哮喘气道炎症机理的研究

MECHANISM OF ANTI-AIRWAY-INFLAMMATION OF ERYTHROMYCIN IN PATIENTS WITH ASTHMA

为探讨红霉素抗哮喘气道炎症的机理，对２６例过敏性哮喘患者肺泡巨噬细胞（ＡＭ），分别加红霉素、地塞米松、生理盐水（空白对照组）培养，测定培养上清液中血栓素Ｂ２（ＴＸＢ２）、肿瘤坏死因子－α（ＴＮＦ－α）、白介素－８（ＩＬ－８）水平。结果显示加红霉素组培养上清液中ＴＮＦ－α、ＩＬ－８水平明显低于空白对照组，ＴＸＢ２水平与空白对照组无差异；地塞米松组培养上清液中ＴＸＢ２、ＴＮＦ－α水平低于空白对照组，ＩＬ－８与空白对照组无差异。提示红霉素可通过抑制哮喘患者肺泡巨噬细胞分泌ΤΝＦ－α、ＩＬ－８而起抗炎作用，且其抗炎机理与地塞米松不完全相同。

To investigate the antiairwayinflammatory mechanism of erythromycin in asthma, 26 patients with atopic asthma were enrolled.Their alveolar macrophages were incubated with erythromycin, dexamethasone and normal saline respectively in vitro. The concentrations of TXB2, TNFα and IL8 in culture supernatants were measured. Results showed the levels of TNFα and IL8 in culture supernatants of AM treated with erythromycin were significantly lower compared with placebo group. The levels of supernatant TNFα and TXB2 of AM incuba ted by dexamethasone were significantly lower compared with placebo group. These findings demonstrated that:Erythromycin have antiinflammatory effect through inhibition of TNFα and IL8 production by alveolar macrophages, and the effect of erythromycin was partialy similar to dexamethasone.