摘要
目的:建立异甾体化合物I C_(13)位伯醇选择性氧化成α醛基的方法。方法:分别采用莫发特氧化(Moffatt Oxidation)、斯文氧化(Swern Oxidation)和氯铬酸吡啶盐(PCC)进行氧化反应。结果:三种氧化方法都能较好的将C_(13)位伯醇氧化成醛基,但在收率和醛基α、β构型比例上有所不同。结论:斯文氧化是一种高效、简便的氧化方法,能选择性的将C_(13)位伯醇氧化成目标α醛基产物,可作为异甾体化合物C_(13)伯醇氧化的可靠方法。
Objective ： To establish an optimal method for selective oxidation of 13-hydroxymethyl of isosteroidal derivative 1 into or-aldehyde. Method： Oxidation procedure was respectively investigated by Moffatt Oxidation, Swern Oxidation and PCC reagent. Result： The conversion from 13-hydroxymethyl into aldehyde was achieved by all these three methods with different yields and isomeric ratios. Conclusion： Swern Oxidation is proved to be an efficient and convenient oxidation method, by which 13-hydroxymethyl can be selectively converted into ct-aldehyde. It can be used as a reliable method for primary alcohols.
出处
《中国药师》
CAS
2009年第8期1003-1005,共3页
China Pharmacist
基金
湖北省自然科学基金重点项目(2008CDA046)
