摘要
目的:研究羧甲基壳聚糖(CMC)对雌二醇凝胶体外透皮吸收的影响。方法:合成CMC,用电位滴定法确定其取代度。以含2%CMC的雌二醇凝胶为试验组,含2%氮酮的雌二醇凝胶为阳性对照组,无任何促透剂的雌二醇凝胶为阴性对照组,通过体外透皮扩散实验得到各组累积透过量,并求出稳态透皮速率。结果:合成得到的CMC取代度为0.52。试验组的累积透过量和稳态透皮速率显著大于阴性对照组(P<0.05),但与阳性对照组相比,差异无统计学意义(P>0.05)。结论:2%CMC与2%氮酮的促透效果相似,值得进一步研究。
Objective : To study the enhancing effect of carboxymethyl chitosan ( CMC ) on the estradiol gel in vitro. Method: CMC was synthesized and the substitution degree was determined by potentiometric titration. Three different kinds of estradiol gels, which was with 2% CMC (testing group) , 2% azone ( positive control group) and without any enhancer ( negative control group) , respectively, were studied. The cumulative penetration ( Q ) and steady penetration rate( J ) in vitro were used as the indices. The cumulative penetration was calculated. Result : The substitution degree of CMC was 0.52. Significant difference was found on the cumulative penetration and the steady penetration rate of testing group when compared with negative control group ( P 〈 0.05 ) , however no significant difference was found when testing group was compared with positive control group ( P 〉 0.05). Conclusion: 2% CMC was an efficient penetration enhancer with similar effect with 2% azone and valuable to be studied further.
出处
《中国药师》
CAS
2009年第8期1025-1028,共4页
China Pharmacist
关键词
羧甲基壳聚糖
雌二醇
凝胶
透皮促进作用
体外
Carboxymethyl chitosan
Estradiol
Gels
Transdermal permeation enhancing
in vitro