某院外科围手术期抗菌药预防性应用的干预性研究

Intervention Study of Perioperative Use of Prophylactic Antibiotics

目的:通过某院外科围手术期抗菌药预防性应用的干预性研究,为临床抗菌药的应用和管理提供依据。方法:分别随机抽取某院手术科室2008年7月和11月出院病人的手术病历各200份,调查分析干预前后围手术期预防性应用抗菌药情况。结果:干预后术前>2h应用抗菌药的比例由11%减少到4.5%(P<0.05),术前0.5～2h应用抗菌药比例由4.5%提高到38%(P<0.05),术后开始应用抗菌药比例由84.5%降到57.5%(P<0.05);抗菌药平均应用时间由7.3d减少到5.2d。干预后围手术期抗菌药预防性应用的合理性明显提高,伤口感染率及医院感染率无明显改变。结论:本研究所采取的抗菌药预防性应用的干预措施具有可行性和有效性,对促进安全、合理地使用抗菌药起到了积极的促进作用。

Objective ： To provide the evidence for the correct application and administration of antibiotics by intervention study of perioperative use of prophylactic antibiotics in a hospital. Method ： Four hundreds surgery patients were sampled randomly from July and Nov. 2008 in a hospital and the perioperative use of prophylactic antibiotics was investigated. Result ： The application ratios of antibacterials 〉 2h before surgery significantly decreased from 11% to 4.5% , 0.5 - 2h before surgery significantly increased from 4. 5% to 38% , after operation significantly decreased from 84.5% to 57.5% respectivelyafter the intervention . The average duration of antibiotic use decreased from 7.3d to 5.2d. Rationality was obviously enhanced for properapplication of antibiotics in perioperative period by the intervention. The rate of wound infection and nosocomial infection was not differenct. Conclusion： The intervened method of antibiotics is feasible and effective. It can promote the correct application of antibiotics.