PASS监测与不合理用药分析

Monitoring on Drug Use by PASS and Analysis of Irrational Drug Use

目的:通过合理用药监测系统(PASS)对我院住院医嘱的用药情况进行汇总分析,发现用药决策中存在的不合理因素。方法:采用PASS系统对我院2007年10月～2008年10月期间住院医嘱进行审查,对不同类型的不合理用药归纳总结。结果:在审核的不合理医嘱中,严重警示占10.7%,较严重警示占35.9%,出现频率最高的不合理用药类型为药物相互作用,占不合理用药总数的48.8%。结论:PASS系统是审查医嘱出现不合理用药的重要工具,其使用需要与临床用药的实际情况相结合,同时也应在使用过程中不断修正改进。临床药师应逐步开展药学监护工作,同临床医师共同审核医嘱,从而减少不合理用药和药物不良反应的发生。

Objecttve： To find the irrational factors in drug use through Prescription Automatic Screening System （PASS）. Method： The prescriptions of inpatients from October, 2007 to October, 2008 in our hospital were monitored by PASS and the results were analyzed statistically. Result： In the irrational prescriptions, the incidence of the most severe warning was 10.9% and 35.9% was severe warning. In all kinds of irrational drug use, the highest frequency of occurrence was drug interaction , which taking for 48. 4%. Conclusion： PASS is an important tool in monitoring irrational drug use , but need to combine with the fact in clinical therapy and PASS should also be modified to adjust to clinical use. Clinical pharmacists should progressively carry out pharmaceutical care with the doctors so as to reduce the occurrence of irrational drug use and ADR.