利多卡因和思密达灌肠治疗非特异性溃疡性直肠炎

Curative Effect Observation of Lidocaine and Smecta in Treatment of Nonspecific Ulcerative Rectitis

目的：观察２％利多卡因和５％思密达灌肠治疗非特异性溃疡性直肠炎的疗效。方法：对７０例非特异性溃疡性直肠炎患者采用双盲随机分组法，进行临床前瞻性对照研究。治疗组３５例用２％利多卡因和５％思密达治疗，对照组３５例用１％氟美松治疗。结果：治疗２周，治疗组临床表现和检查结果明显改善；总有效率，治疗组９４．３％，对照组８７．５％，两组比较具有统计学意义（Ｐ＜０．０１）。结论：利多卡因阻断直肠粘膜神经支配，减少递质释放；

bjective:To find a more effective treatment of nonspecific ulcerative rectitis by using combined 2% lidocaine hydrochloride with 5% smectaMethods:Clinical prospective study was conducted with double blind method on 35 patients treated with combined 2% lidocaine and 5% smectaA control group was established and treated with 1% dexamithasoneResults:Two weeks later,clinical features and examinations were improved in the treated group than those of the control.the overall effective rate was 943% in the treated group and 875% in the controlThe two groups were different significantly (P<0.01)Conclusion:Lidocaine hydrochloride blocks neurecrchy of rectal mucosa,decreases the release of neurotransmitters and Smecta promotes the repair of mucosal lesion and stops the local bleeding