一氧化氮与前列环素对内皮素-1生物学效应的调节作用

Effect of nitric oxide and prostacyclin on regulating endothelin-1 biological function

目的和方法：应用肝脏原位灌注模型，观察内皮素－１（ｅｎｄｏｔｈｅｌｉｎ－１，ＥＴ－１）对肝脏的损伤作用，以及一氧化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）和前列环素（ｐｒｏｓｔａｃｙｃｌｉｎ，ＰＧＩ２）对ＥＴ－１生物学效应的调节作用。结果：ＥＴ－１能使肝细胞浊肿变性，增加脂质过氧化物生成和酶的漏出。ＮＯ合成抑制剂能使ＥＴ－１的肝损伤作用加重，ＰＧＩ２和消炎痛能部分减轻ＥＴ－１的肝损伤作用。结论：ＮＯ。

AIM and METHOD:On the perfusion model of rat liver in situ, the effects of endothelin-1(ET-1) on hepatic damage was studied, the effect of nitric oxide and prostacyclin on regulation ET-1 biological function was observed. RESULTS:ET-1 significantly induced hepatic edema and increased production of lipid peroxidation and leakage of enzyme. An administration of LNNA, an inhibitor of NO(nitric oxide), augmented the hepatic damage induced by ET-1, prostacyclin and indomethacin partially decreased the hepatic damage induced by ET-1. CONCLUSION:NO and PGI2 may regulate ET-1 biological function.