Ⅱ型糖尿病的早期危险因素研究

Study on Ealyer Risk Factor of NIDDM

对湖南长沙市４所医院中的２００对Ⅱ型糖尿病（Ｎｏｎ－Ｉｎｓｕｌｉｎ－ＩｎｄｅｐｅｎｄｅｎｔＤｉａｂｅｔｅｓＭｅｌｉｔｕｓ，ＮＩＤ－ＤＭ）和非Ⅱ型糖尿病进行１∶１病例对照研究，调查其少儿阶段的暴露情况，采用条件Ｌｏｇｉｓｔｉｃ回归分析。结果显示：ＮＩＤＤＭ的早期危险因素有：油炸食物（Ｂｉ＝２．４９５，ＯＲ＝１２．１２２）、甜食（Ｂｉ＝２．３６９，ＯＲ＝１０．６８７）、腮腺炎史（Ｂｉ＝２．２３９，ＯＲ＝９．３００）、饥饿（Ｂｉ＝１．０６５，ＯＲ＝２．９０１）以及暴饮暴食（Ｂｉ＝０．８４９，ＯＲ＝２．３７７）；而蔬菜（Ｂｉ＝－２．３１３，ＯＲ＝０．１００）对ＮＩＤＤＭ有保护作用。提示少儿阶段的生活饮食因素和病毒感染很可能与Ⅱ型糖尿病的发生有密切关系，因此，ＮＩＤＤＭ的预防要从小抓起，提倡少儿阶段合理平衡饮食，积极预防病毒感染，是早期预防Ⅱ型糖尿病的重要对策。

subjects were selected in the study from 4 hospitals at Changsha in Hunan.200 cases(NIDDM) and 200 age sex matched controls(same sex and age difference less than 5 years) were obtained by standard questionnaire for eating behavior and other factors in the adolescence (aged ≤15).Conditional logistic regression analysis was used for data analysis.The results showed that five possible risk factors were 1)liking deep fried foods(Bi=2 495,OR=12 122);2)more consumption of sugar(Bi=2 369,OR=10 687);3)infected mumps(Bi=2 239,OR=9 300);4)hunger(Bi=1 065,OR=2 901);5)over eating and drinking(Bi=0 849,OR=2 377).The protective factor was more consumption of vegetables (Bi= 2 313,OR=0 100).It suggests that NIDDM prevention should be starting in the earlier adolescence by reasonable and balanced diet,good eating behavior and preventing virus infection for control the incidence of NIDDM.