糖尿病视网膜病变与脂质代谢的关系

THE RELATIONSHIP BETWEEN LIPID METABOLISMAND DIABETIC RETINOPATHY

目的探讨脂质代谢与糖尿病视网膜病变之间的关系。方法检测１６８例糖尿病病人血清中的总胆固醇（ＣＨ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、载脂蛋白Ａ１（ＡｐｏＡ１）、载脂蛋白Ｂ１００（ＡｐｏＢ１００）和脂蛋白（ａ）［Ｌｐ（ａ）］；并同时观察这些病人的视网膜情况。结果伴有糖尿病视网膜病变的病人血清中的总胆固醇、ＬＤＬ－Ｃ和Ｌｐ（ａ）较不伴有糖尿病视网膜病变的病人明显增高，而ＨＤＬ－Ｃ、ＡｐｏＡ１和ＡｐｏＡ１／ＡｐｏＢ１００比例则较无糖尿病视网膜病变的病人明显降低。经Ｌｏｇｉｓｔｉｃ回归分析，总胆固醇、ＨＤＬ－Ｃ和ＡｐｏＡ１／ＡｐｏＢ１００作为独立的因素仍然与糖尿病视网膜病变相关。结论脂质代谢的异常，可能是糖尿病视网膜病变发生和加重的重要因素。

おURPOSE To investigate the relationship between lipid metabolism and diabetic retinopathy.METHODS Levels of serum total cholesterol(CH), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C),Apo-protein Al(ApoA1),Apo-protein B100 (ApoB100), ApoA1/ApoB100 ratio,lipoprotein(a) , levels were compared between 168 patients with and without diabetic retinopathy.RESULTS We found that CH, LDL-C and Lp(a) levels were obviously high and HDL-C, ApoA1 and ApoA1/ApoB100 levels were obviously low in diabetic retinopathy patient group. After logistic regression analysis, CH, HDL-C and ApoA1/ApoB100 as independent factors were still correlated with diabetic retinopathy.CONCLUSIONS Abnormal serum lipid levels may play an important role in the generation and deterioration of diabetic retinopathy.