红斑狼疮生物疗法的研究进展

Research development of biological therapy for lupus erythematosus

红斑狼疮是一种病因未明的慢性自身免疫性炎症性疾病，目前缺乏有效的治疗手段。红斑狼疮患者和小鼠模型显示了多方面的免疫学异常，在此基础上研发了影响自身反应性B细胞活化的治疗性抗体，正在进行临床检测。另外。

Lupus erythematosus is a chronic autoimmune inflammatory disease with largely unknown etiopathogenesis and no effective therapy. Human patients and murine models of lupus erythematosus manifest a wide range of immunological abnormalities. Therapeutic antibodies which affect the activation of potentially autoreactive B ceils have been developed and are being tested in clinical trials. In addition, preelinical studies have provided proof for the feasibility and efficacy of gene therapy in human lupus erythematosus.