反向疫苗学：恶性疟疫苗研制新策略

Reverse vaccinology：a new strategy to develop falciparum malaria vaccine

基因组技术和生物信息学的发展催生了反向疫苗学，它是从全基因组水平筛选保护性免疫抗原的新方法。疟疾主要由4种人体疟原虫引起。恶性疟原虫14条染色体上的全基因组序列测定目前已经完成，因此，利用反向疫苗技术研制恶性疟候选疫苗将是有效的新策略。

Genome technology and bioinformatics lead to the development of reverse vaccinology, which is a new method of screening the protective immunity antigen from the whole genome level. Malaria is mainly caused by four species of human Plasmodium parasites. The work of sequencing genome on 14 chromosomes of Plasmodiumfalciparum has been completed. Therefore, studying on Plasmodiumfalciparum candidate vaccine with reverse vaccine technology will become a new effective strategy.