温度敏感型瞬时受体电位通道与皮肤神经源炎症和瘙痒

Role of thermoTRP channels in cutaneous neurogenic inflammation and itch

温度敏感型瞬时受体电位通道(TRP channels)包括TRPV1,TRPV2,TRPV3,TRPV4,TRPM8和TRPA1,在皮肤上表达于皮肤感觉神经,角质形成细胞及肥大细胞。温度敏感型TRP通道可被各种物理和化学刺激致敏或激活,激活的温度敏感型TRP通道不但介导温度感知和调节,而且还参与痛痒觉发生以及皮肤神经源炎症发生,因此,温度敏感型TRP通道已成为治疗炎症性皮肤病和瘙痒的重要分子靶标。此外,利用以温度敏感型TRP通道为中心建立的知觉基本句法和分子底物,能辨别和重新确定感觉分类,并且有助于对瘙痒或瘙痒性皮肤病发病机制进行分析和处理。

The temperature-sensitive transient receptor potential （TRP） channels,is also called thermoTRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal ceils （e. g. keratinocyte, mast cell） of the skin. ThermoTRP channels are activated/sensitized by physical and chemical mediators, which participate in thermosensation and thermoregulation,so that they are key players in pruritus or pain pathogenesis. ThermoTRP channels are also involved in cutaneous neurogenic inflammation, thus they are regarded as molecular targets for future therapy in skin inflammation,pruritus and pain. In addition,following a basic syntax and molecular substrate of nociception and pruriception established by TRP channels-centered concept,the sensory categories can be distinguished and re- defined. ThermoTRP channels should be taken into account when analyzing the pathogenesis and management of itch or pruritic dermatosis.