胆道结石患者胆汁中头孢曲松钠的浓度分布研究

Assessment of Biliary Excretion of Ceftriaxone Sodium in Humans

目的研究头孢曲松钠在胆道结石患者胆汁中的浓度分布,为胆道感染合理用药提供参考。方法12例因胆道结石患者于术前半小时静脉滴注头孢曲松钠2.0g,术中收集胆囊和胆总管胆汁;采用HPLC法行胆汁药物浓度测定。结果头孢曲松钠在胆总管和胆囊中的浓度分别为264.43±166.46μg/ml和85.39±48.16μg/ml。结论头孢曲松钠在胆道结石患者胆汁中浓度较高,可作为临床上预防和治疗肝胆系统感染较好的抗生素。

Objective To study biliary excretion of cefiriaxone sodium in humans. Methods Twelve biliary calculi patients were infused with a single dose of 2.0g ceftriaxone half an hour before operation and the common bile duct bile and gallbladder bile samples were collected in the operations. The bile drug concentrations were assayed by HPLC. Results The results of clinical study on the bile drug showed that the concentrations （C） of ceftriaxone in common bile duct and gallbladder were （264.43 ± 166.46）μg/ml and （85.39±48.16） μg/ml, respectively. Conclusion Ceftriaxone reaches high concentrations in humans＇ bile, and it could be chosen as a good antibiotics for the treament of biliary infection.