内皮素1在肺移植后闭塞性细支气管炎中的效应

Effect of endothelin-1 on obliterative bronchiolitis after lung transplantation

肺移植后移植物的存活受限于闭塞性细支气管炎的出现。近年来的研究发现,内皮素1在闭塞性细支气管炎的发生发展中起到了一个较为重要的作用,内皮素1具有促炎症反应和促成纤维细胞增殖的作用。而非选择性的内皮素1受体拮抗剂波生坦则能够减弱内皮素的作用,明显减弱气道的闭塞。波生坦主要是通过抑制平滑肌细胞的增殖和明显减少免疫反应性细胞白细胞介素1β和白细胞介素2的数量而起作用的。文章通过相关方面文献的检索,总结了内皮素1在肺移植后闭塞性细支气管炎中的作用,并进一步观察波生坦在治疗闭塞性细支气管炎过程中所发挥作用。

The survival of graft is limited to appearance of obliterative bronchiolitis （OB） after lung transplantation. Recent studies have shown that endothelin-1 exhibits a very important role during the occurrence and development of O8. The endothelin-1 has the effects of promoting inflammation and the proliferation of fibroblasts. Bosentan as a non-selective endotbelin-1 receptor antagonist can reduce the effect of endothelin-t and significantly decrease tracheal occlusion. The bosentan plays its role by suppressing smooth muscle cell proliferation and obviously reducing the number of immunoreactive cells （interleukin-1 β and interleukin-2）. Through retrieval of relate references, the article summarizes the effect of endothelin-1 in OB after lung transplantation, and further observes the effect of bosentan on OB treatment.