补体与移植排斥反应

Complement and allograft rejection

排斥反应影响着移植器官的功能和结局,近年来有关补体与器官移植的研究中发现补体广泛参与器官移植排斥反应。移植受者在供者移植物抗原刺激下,可以产生各种抗体,这些抗体与相应的抗原结合,形成抗原抗体复合物,进而激活补体。而补体在序列活化过程中所释放出的一些递质及活性片段可直接破坏移植物。补体参与急性、慢性以及超急性排斥反应,其具体机制有待更进一步的研究,并且为研究排斥反应的发生机制提供了一个崭新的方向。

The function and result of transplanted organ＇s can be affected by rejection. It is found that complement is involved in organ-graft refection in recent researches. In recipient, the complement characterized by the response to antigen-antibody （immune） complexes, can release medium and active fragment to make the graft damaged. It is necessary to do further research on the mechanism of the complement in acute rejection, chronic rejection and hyperacute rejection.