局部晚期鼻咽癌患者放化综合治疗临床观察

Clinical analysis of radio-chemotherapy for patients with locally advanced nasopharyngeal carcinoma

目的:探讨Ⅲ、ⅣA期鼻咽癌患者放化综合治疗的疗效和影响预后因素。方法:选取符合入组条件的Ⅲ、ⅣA期初治鼻咽癌患者156例,分为单纯放疗组(78例)和放化综合治疗组(78例)。用Kaplan-Meier方法计算生存率,用Cox比例风险模型分析预后影响因素。结果:单纯放疗组的3年总生存率为42.8%(33/78),放化疗综合治疗组为75.9%(59/78),两组比较差异有统计学意义,P=0.007。临床分期、N分期、是否化疗、治疗后是否残留是影响鼻咽癌患者生存的相关因素。结论:放化综合治疗对Ⅲ、ⅣA期鼻咽癌效果较好。

OBJECTIVE： To investigate the efficacy and prognosis of radio-chemotherapy for patients with nasopharyngeal carcinoma in stage Ⅲ and ⅣA. METHODS： A total of 156 patients with nasopharyngeal carcinoma in stage Ⅲ and ⅣA were divided into two groups： radio- therapy group（78）, and radio-chemotherapy group （78）. The Kaplan- Meier method was used to calculate the survival rate. The proportional- hazards regression model （Cox model） was used to research prognosis factors. RESULTS： The overall survival rate in the radiotherapy group was 42.8% （33/78）, and 75. 9% （59/78） in the radio-chemotherapy group（P=0. 007）. The clinical stage, N stage, whether to chemotherapy, whether to remain were the interrelated factors of the survival. CONCLUSION： Radio-chemotherapy is more effect on patients with nasopharyngeal carcinoma in stage Ⅲ and ⅣA.