摘要
目的:探讨葡萄球菌肠毒素瘤体内注射联合放射治疗复发性颈部淋巴结转移癌的临床应用价值。方法:将65例患者随机分为治疗组与对照组。治疗组采用葡萄球菌肠毒素瘤体内注射联合肌肉注射配合放射治疗,对照组仅行放射治疗。两组放射照射剂量均为DT65~70Gy/6.5~7周。结果:治疗结束后治疗组33例患者中,CR15例(45.5%),PR15例(45.5%),RR为90.9%(30/33),NC3例,PD0例。而对照组32例患者中,CR7例(21.9%),PR15例(46.9%),RR为68.8%(22/32),NC10例,PD0例(P<0.05)。治疗结束3个月后复查,结果亦相同。另外对患者的生存质量也有明显的改善作用,P<0.05。结论:葡萄球菌肠毒素瘤体内注射联合肌肉注射,可使颈部转移瘤体内该药物浓度增高,配合放射治疗、增强了其对肿瘤细胞的直接杀伤作用,具有较高的肿瘤消退率、并且改善了患者的生存质量。
OBJECTIVE: To evaluate the effect of staph- yloentero-toxin(SE)intratumoral injection plus radiotherapy in the treatment of recurrent metastases carcinoma of the head and neck. METHODS: A total of 65 patients with recurrent metastases carcinoma of the head and neck were divided in two groups by random: the test and the control. The patients in the test group were treated with SE intratumoral injection and intramuscular plus conventional radiotherapy and ones in the control group were treated with radiotherapy only. The radio- therapy dose was 65 - 70 Gy/(6.5 -- 7) weeks. RESULTS : The control rates were CR 45.5%(15/33), 21.9%(7/32), PR 45.5%(15/33), 46.9% (15/32), RR 90.9% (30/33), 68.8%(22/32), in the test group and control group, respec tively, P〈0. 05, and the guality of life improved in the test groups compared with the control, P〈0.05. CONCLUSIONS: SE intratumoral injection and intramuscular plus radiotherapy is beneficial to recurrent metastases carcinoma of the head and neck. It may improve the quality of life of the patients.
出处
《中华肿瘤防治杂志》
CAS
2009年第12期937-939,共3页
Chinese Journal of Cancer Prevention and Treatment