摘要
目的：探讨A型内毒杆菌毒素治疗膀胱过度活动症的疗效。方法：对本院46例膀胱过度活动症患者应用A型肉毒杆菌毒素进行治疗。结果：所有患者尿频症状治疗后均得到改善，显示一定临床疗效和尿动力学改善。平均每次尿量明显增加，昼排尿次数、夜排尿次数、日均尿失禁次数明显减少，与治疗前比较，差异有统计学意义（P〈0．05）。未发现全身性严重不良反应，局部副作用轻微。结论：OAB的病因尚未完全清楚，但是BTx—A治疗OAB疗效0满意，且不良反应轻，较为安全。但所有的研究结果均未经大规模、多中心、对照及双盲实验证实，所以对于BTX—A的注射剂量、方法、间隔时间等尚需进一步研究。
Objective Discuss botulinum toxin type A treatment overactive bladder effect. Methods 46 eases overactive bladder application patients were used botulinum toxin type A to treatment in our hospital. Results All patients frequent symptoms were improved after treatment, showed a certain clinical efficacy and urodynamics improvement. Average urine volume increased significantly, the number of daytime voiding frequency, night urination frequency, and daily incontinence were significantly reduced, compared with before treatment, there were significant differences（P〈0.05）, no serious systemic adverse reactions occurred, minor local side effects. Conclusion Although the cause of OAB has not yet entirely clear, BTX- A treatment OAB effect satisfaction, adverse reactions and light, is safer, but all of the findings are without a large-scale, multi-center, double -blind experimental control confirmed, therefore, we requires further study for the injection of BTX-A dose, method, time interval.
