依贝沙坦治疗原发性高血压60例的临床效果观察

The observation of clinical effect of 60 LIU Shi-lan essential hypertension cases with Irbesartan treatment

目的：观察血管紧张素受体拮抗剂Ⅱ（AT-Ⅱ）依贝沙坦对原发性高血压患者的降压疗效及副作用的影响。方法：原发性高血压患者60例，口服依贝沙坦100mg／d，8周为1个疗程。治疗前后采用偶测血压及24h动态血压监测，对比治疗前后NO，NOS指标。结果：依贝沙坦治疗后偶测血压，24h动态血压监侧均明显降低；NO，NOS明显升高，显示NO，NOS与血压呈明显负相关关系，且治疗过程中副作用小。结论：依贝沙坦有利于缓解心衰症状，降压效果明显，和同类药相比，具有较小的副作用，是一种很有效的高血压降压药。

Objective： To observe the effects of antihypertensive impaction and side effects of angiotensin receptor blockers Ⅱ （Irbesartan） in patients with primary hypertension. 60 cases of essential hypertension patients took orally Irbesartan 100mg/d ,8 weeks for a period. Methods： Measured blood pressure using accidentally monitoring and 24h dynamical blood pressure monitoring, and compared to NO, NOS index before and after the treatment. Results： 24h blood pressure monitoring showed the blood pressure significantly reduced after Irbesartan treatment. NO, NOS increased significantly which displayed NO, NOS and blood pressure is obviously inter--negative correlation. Affection was tiny during the treatment side. Conclusion： Irbesartan is propitious to alleviate symptoms of heart failure with significant antihypertensive effects, and compared with other medicine, it has smaller side effects. So Irbesartan is a very kind of effective blood pressure medicine.