摘要
目的:观察凯西莱(硫普罗宁)在恶性肿瘤患者接受化疗药时对化疗性肝损害的预防和治疗作用。方法:将154例患恶性肿瘤的患者分为两组,预防组78例,在化疗同时加用凯西莱;对照组76例单纯化疗,对出现肝损害的患者(28例)加用凯西莱治疗。结果:预防组肝损害的发生明显低于对照组,有显著性差异(P<0.01);对照组中有肝损害的患者加用凯西莱治疗后肝功能指标有明显改善,有显著性差异(P<0.01)。结论:凯西莱对恶性肿瘤患者化疗性肝损害的预防和治疗疗效显著,值得临床推广。
Objictive： To observe the effects of tiopronin in the prevention and treatment of chemical hepatitis in patients with malignant tumor. Methods：Total of 154 patients with malignant tumors were divided into two groups. Prevention group（78cases） received anti - tumor and tiopronin treatment. The control group （ 76cases ） only received anti -tumor treatment,the patients（28cases） of the control group received tiopronin for chemical hepatitis. Results： The rates of hepatotoxicity of the prevention group was significantly lower than the control group. The difference was significant （P 〈 0.01 ） ; The control group in patients with hepatotoxicity with tiopronin liver function after treatment showed a significant improvement, there are significant differences（ P 〈 0.01 ）. Conclusion：Tiopronin is effective in the prevention and treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors, and worthy to be popularized.
关键词
凯西莱
恶性肿瘤
化疗药物性损肝害
Tiopronin
Malignant tumor
anti - tumor agent
hepatotoxicity
