期刊文献+

弥漫性轴索损伤48例临床分析 被引量:3

Clinical analysis for 48 cases of diffuse axonal injury
原文传递
导出
摘要 目的探讨弥漫性轴索损伤(DAI)的发病机制、临床特点、诊断及治疗方法。方法观察分析48例DAI患者的临床表现、影像学表现、治疗及预后。结果按GOS评分结果,治愈18例,中残12例,重残或植物生存10例,死亡8例。结论保持呼吸道通畅,防治脑水肿,采用高压氧及早期应用大剂量纳络酮等综合治疗,是提高DAI救治成功率的关键。 Objective To discuss the clinical feature,diagnostic main points and treatment of diffuse axonal injury(DAI). Methods The clinical materials and imaging findings and treatment and prognosis of 48 cases with DAI were analyzed retrospectively. Results 18 cases showed a good outcome, while 12 were moderately disabled, 10 severely disabled or survived in a permanent vegetative state and 8 cases died. Conclusion To preserve the fluent respiratory tract, to control intracranial pressure, to treat with hyperbaric oxygenation and high-dose naloxone in early time were crucial in clinical practice to DAI.
出处 《中国基层医药》 CAS 2009年第7期1197-1198,共2页 Chinese Journal of Primary Medicine and Pharmacy
关键词 弥漫性轴索损伤 诊断 治疗 Diffuse axonal injury Diagnosis Treatment
  • 相关文献

参考文献6

  • 1Levi L,Guilburd J N,Lemberger A,et al.Diffuse sxonal injury:analysis of 100 patients with radio logical signs.Neurology,1990,27(7):429-432.
  • 2Hurley,Dan.MRI Program Identifies Diffuse Axonal Injuryat One Week Post-Injury.Neurology Today,2007,7(10):1-14.
  • 3Parizei P M,Van Geethem J W,Ozsarlak O,et al.New developments in the neuroradiological diagnosis of craniocerebral trauma.Eur Radiol.2005,15(3):569-581.
  • 4匡远深.纳络酮注射液治疗急性颅脑损伤有显效[J].中华医学杂志,2001,81(2):101-101.
  • 5江基尧,方乃成,张建平,李维平,徐蔚,朱诚,许文辉,包映辉,王勇,邱永明,罗其中.亚低温治疗重型颅脑损伤前瞻性临床多中心对照研究[J].上海第二医科大学学报,2005,25(3):270-272. 被引量:52
  • 6郁树亮,陈华,韩志安.弥漫性轴索损伤的诊断与治疗[J].中国基层医药,2008,15(1):74-75. 被引量:3

二级参考文献19

  • 1Adams JH, Gmbam DI, Gennaretti TA, et al. Diffuseaxonal injury in non-missile injury. J Neurol Neurosury Psyohiatry, 1994, 54 (4) :481-483.
  • 2Holzer M, Martens P, Roine R, et al. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest[J]. N Eng J Med, 2002, 346:549-556.
  • 3江基尧 朱减 罗其中.颅脑损伤临床救治指南[M].上海:第二军医大学出版社,2003.1-222.
  • 4江基尧.亚低温与脑损伤的基础与临床[M].上海:第二军医大学出版社,1998.1-83.
  • 5Jiang JY, Gao GY, Li WP, et al. Early indicators of prognosis in 846 cases of severe traumatic brain injury[ J ]. J Neurotrauma,2002,19 : 869 - 874.
  • 6Jiang JY, Yu MK, Zhu C. Effect of long-term mild hypothermia on patients with severe traumatic brain injury: 1 year follow-up of 87 cases[J]. J Neurosurg, 2000, 93(4): 546-549.
  • 7Teasdale G, Jennet B. Assessment of coma and impaired consciusness: a practical scale[J]. Lancet, 1974, 2:81 -84.
  • 8Clifton GL, Jiang JY, Lyeth BG, et al. Marked protection by moderate hypothermia after experimental TBI [ J ]. J Cereb Blood Flow Metab, 1991, 11: 114- 121.
  • 9Clifton G, Miller ER, Chun SC, et al. Lack of effect of induction of hypothermia after acute brain injury [ J ]. N Eng J Med, 2001, 344:56 - 61.
  • 10Clifton GL, Miller ER, Choi SC, et al. Hypothermia on admission in patients with severe brain injury[J], J Neurotrauma, 2002, 19:293 - 298.

共引文献55

同被引文献21

  • 1王振宇,胡择勇,张绩隆,李博,黄永安,董连强.颅脑损伤合并高血糖症及其临床意义[J].中国临床神经外科杂志,1999,4(1):12-13. 被引量:36
  • 2高亮,周良辅,黄峰平,金毅,吴雪海,谢嶸,吴惺,谢清,姚成军,朱剑虹.脑室内颅内压持续监测和阶梯式治疗重型颅脑外伤[J].中华神经外科杂志,2007,23(7):507-509. 被引量:71
  • 3Kiening KL, Hartl R, Unterberg AW, et al. Brain tissue pO2-monitoring in comatose patients: implications for therapy[ J]. Neurol Res, 1997,19(3) :233-240.
  • 4Turner R J, Dasilva KW, O'Connor C, et al. Magnesium gluconate offers no more protection than magnesium sulphate following diffuse traumatic brain injury in rats [ J]. J Am Coll Nutr, 2004,23 ( 5 ) : 541S-544S.
  • 5Veyna RS, Seyfried D, Burke DG, et al. Magnesium sulfate therapy after aneurysmal subarachnoid hemorrhage [ J ]. J Neurosurg, 2002, 96(3) :510-514.
  • 6Yoon KW,Mitehell HL,Broder LD,et al.Traumatic induced neu rotoxicity in rat hippocampal neurons.Stroke,1996,27(2):122-126.
  • 7Kilpatrik MM, Lowry DW, Firlik AD, et al. Hyperthermia in the neu- rosurgical intersive care unit.Neurosurgery,2000,47:850-856.
  • 8Maeda T, Hashizume K, Tanaka T. Effect of hypothermia on kainie acid-induced limbic seizures:an electroencephalographic and IC-de- oxyglucose antoradiographic study.Brain Res, 1999,818:228-235.
  • 9Atkins CM, Oliva AA Jr, Alonso OF, et al. Hypothermia treatment potentiates ERK1/2 activation after traumatic brain injury [J]. Eur J Neurosci, 2007, 26(4): 810-819.
  • 10Jia F, Mao Q, Liang YM, et al. Effect of post-traumatic mild hypothermia on hippocampal cell death after traumatic brain injury in rats[J]. J Neurotrauma, 2009, 26(2): 243-252.

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部