1，6二磷酸果糖对恶性骨肿瘤化疗患者心脏保护作用的研究

Cardiac protection effect of fructose-1, 6-diphosphate in patients with primary bone cancer treating with chemotherapy

目的探讨原发性恶性骨肿瘤化疗患者静脉应用1，6-二磷酸果糖对心脏的保护作用。方法将化疗9次的178例患者分为未应用心脏保护类药物组93例（A组）和应用心脏保护类药物组85例（B组），比较两组患者心电图差异。结果B组患者心电图异常事件显著少于A组患者（30与81，P〈0．05）。结论1，6二磷酸果糖可有效减轻恶性骨肿瘤患者辅助化疗引起的心脏损伤。

Objective To investigate the cardiac protection effect of venous fructose-1,6-diphosphate in patients with primary bone malignant tumors. Methods 178 patients received 9 times of chemotherapy were randomly divided into non-eardiae protective therapy group （A group）and cardiac protective therapy group（ B group）. The cardiae toxicity was reflected by abnormal electrocardiographic changes. The abnormal electrocardiographic changes were compared in two groups. Results Abnormal electrocardiographic changes were significantly decreased in B group compared with A group （30 vs 81 ,P 〈. 05 ）. Conclusion The cardiac protective medicine fructose-1,6-diphosphate efficiently decreased the cardiac toxicity in patients with primary bone malignant tumors treating with chemotherapy.