颈动脉粥样硬化与缺血性脑血管病的临床研究

Clinical research of carotid artery atherosclerosis and ischemic cerebrovascular disease

目的探讨颈动脉粥样硬化与缺血性脑血管病的关系。方法对212例患者(包括脑梗死患者和缺血性脑血管病高危人群)及60例健康对照组进行双侧颈动脉超声探查,测量颈总动脉后壁的内膜中层厚度(IMT),了解有无斑块形成,进行斑块质地判断。结果病变组IMT与对照组相比差异有统计学意义(P<0.01),病变组以软斑及溃疡斑为主,对照组以扁平斑、硬斑为主,高于对照组(P<0.05)。斑块的好发部位以颈动脉窦部(BIF)处最为常见。结论缺血性脑血管病患者颈动脉粥样硬化斑块以不稳定的软斑及溃疡斑为主,颈动脉粥样硬化斑块类型与缺血性脑血管病的关系密切。

Objective To discuss the relationship between the carotid artery atherosclerosis and ischemie cerebrovaseular disease. Methods To compare 212 patients（including cerebral infarction patients and high risk group of ischemic cerebrovascular disease） and 60 healthy people with the method of both arteries ultrasonography, measure the back arteriae carotis communis IMT, search the formation of the plaque,and estimate the quality of the plaque. Results Pathological grouprs IMT had obvious difference with the control group（P〈0.01）. Pathological group mainly consisted of weak plaque and ulcerous plaque, which were more than those in the control group（P〈0.05）, those in the control group mainly consisted of flat and hard plaque. The plaque was most easily to occur at the BIF. Conclusion The patients of ischemic cerebrovascular disease have carotid artery atherosclerosis Which is mainly formed of unstable weak plaque and ulcerous plaque,and various types of plaque of carotid artery atherosclerosis have closed relationship with ischemic cerebrovascular disease.