纳豆冻干粉对小鼠免疫功能作用的研究

Immunopotentiating effect of freeze-drying Natto powder on mice

以小鼠为实验对象,分别以75、150、300mg.kg-13个剂量组的纳豆冻干粉给予小鼠灌胃30天后,进行小鼠细胞免疫指标(脏器/体重指数、迟发型变态反应(DTH)和体液免疫指标(抗体生成细胞、血清溶血素)的测定。研究结果发现,各剂量组的各项检测结果与空白对照组比,纳豆冻干粉对小鼠体重、脏器重量影响不明显,但能够促进小鼠迟发型变态反应;提高小鼠抗体生成细胞数和血清溶血素水平,且当剂量达到150mg.kg-1以上时,具有明显的提高免疫力的作用。本项研究表明纳豆冻干粉具有增强小鼠细胞及体液免疫功能的作用。

To study the effect of freeze-drying natto powder on the mice immune system. The mice were feed with freeze-drying natto powder at the dose of 75,150 and 300mg·kg^-1. respectively, once a day for 30 days. Index of organs/body, delay allergy （DTH）, the number of the antibody-producing cells and the blood-serum erythrocytolysin were measured to judge the effect of freeze-drying natto powder on the immune system. All the examination results of the experimental group in comparison with the control group showed that there was no significant effect on the mice body weight, but the DTH was enhanced, the quantity of the antibody-producing cell and the blood-serum erythrocytolysin were raised up. When the dose reached to 150mg·kg^-1, the immunity-enhancing effect was obvious. This research suggested that freeze-drying natto powder could enhance mice immune function.