不同时期H_5N_1病毒的HA和NA基因进化树及基因变异率线性回归分析

Phylogenetic and linear regression analysis on HA and NA gene of H_5N_1 virus during different periods

利用Genbank上从1996-2007年的所有的H5N1禽流感病毒的HA基因和NA基因进行进化树分析,基因变异率线性回归分析表明1996-2000年的HA基因和NA基因的变异率要明显低于2000-2007年间的变异率,其原因也许与2000-2007年间东南亚各国大量使用疫苗有关。

The sequences of HA genes and NA genes of all H5N 1 avian influenza viruses isolated from 1996 to 2007 had been downloaded from GenBank for phylogenetic analysis. Linear regression results indicated that the evolutionary rates of HA and NA gene from 1996 to 2000 were significantly lower than those from 2000 to 2007. This result probably was associated with the massive application of H5N1 inactivated vaccine in the countries of South East Asian from 2000 to 2007.