摘要
In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro. ？2009 Hong Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
In order to find compounds with superior bioactivity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents. Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro. ？2009 Hong Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金
supported by the National Natural Science Foundation of China(No.30873363)
the Great Program of Science Foundation of Tianjin(No.06YFJZJCO2700)
Program of Science Foundation of Tianjin(No.08JCYBJC070000).
