摘要
15 成员 macrolides 的一系列新奇暗淡 ers 被综合并且评估。暗淡 ers 对抗生素的一种易受影响的 S 展出了优秀活动。肺病，但是没对抗生素的一种抵抗的 S 显示出任何改进活动。pneumoniae 由 erm 基因编码了。
A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
基金
supported by the National Natural Science Foundation of China(No.2087208 1)
Natural Science Foundation of Shandong(No.Y2006C3 1)
Shandong Science and Technology Promotion Project(No.2005GG3202098).
