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B7-H1在类风湿关节炎患者血清中的水平及相关性分析 被引量：1

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摘要 类风湿关节炎（rheumatoid arthritis，RA）是一种以累及周围关节为主的系统性炎症性的自身免疫性疾病。近年来，参与T淋巴细胞激活的一些共刺激分子在免疫调节中的作用越来越受到广大研究者的重视，已成为一个新的研究热点。
作者 孙玮 刘秀梅
机构地区 山西医科大学第一医院风湿免疫科
出处 《中国药物与临床》 CAS 2009年第8期699-701,共3页 Chinese Remedies & Clinics
关键词 类风湿关节炎 关节炎患者 B7-H1 自身免疫性疾病 血清 淋巴细胞激活 共刺激分子 免疫调节
分类号 R593.22 [医药卫生—内科学] R151 [医药卫生—营养与食品卫生学]
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参考文献9

  • 1Dong H,Zhu G,Tamada K,et al.B7-H1,a third member of the B7 family,costimulates T-cell proliferation and interleukin-10 secretion.Nat Med,1999,5(12):1365-1369.
  • 2陈瑞林,陶怡,黄文辉,黄成辉.类风湿关节炎患者外周血CD4^+T细胞上CD28表达异常的研究[J].中华风湿病学杂志,2006,10(5):308-310. 被引量：3
  • 3蔡青,张军,刘彧,张兰玲,韩星海,沈茜.可诱导共刺激因子在类风湿关节炎外周血和关节滑液细胞的表达[J].中华风湿病学杂志,2006,10(11):650-653. 被引量：3
  • 4Latchman Y,Clive R,Wood TC,et al.PD-L2 is a second ligand for PD-1 and inhibits T cell activation.Nat Immunol,2001,2(3):261-268.
  • 5Dong H,Strome SE,Salomao DR,.et al.Tumor-associated B7-H1 promotes T-cell apoptosis:A potential mechanism of immune evasion.Nat Med,2002,8(8):793-800.
  • 6Freeman GJ,Sharpe AH,Kuchroo VK,et al.Protect the killer:CTLs need defenses against the tumor.Nat Med,2002,8(8):787-789.
  • 7Freeman GJ,Long AJ,lwai Y,et al.Engagement of the PD-1 im munoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.J Exp Med,2000,192(7):1027-1034.
  • 8LaCier AJ,Pober JS.Immune functions of humans endothelial cells are modulated by overexpression of B7-H1 (PD-L1).Hum Immunol,2006,67(8):568-578.
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二级参考文献32

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  • 3Warrington KJ,Takemura S,Goronzy JJ,et al.CD4+,CD28-T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems.Arthritis Rheum,2001,44:13-20.
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  • 5Vallejo AN,Nestel AR,Schirmer M,et al.Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity.J Biol Chem,1998,273:8119-8129.
  • 6Martens PB,Goronzy JJ,Schaid D,et al.Expansion of unusual CD4+ T cells in severe rheumatoid arthritis.Arthritis Rheum,1997,40:1106-1114.
  • 7Pawlik A,Ostanek L,Brzosko I,et al.The expansion of CD4+CD28-T cells in patients with rheumatoid arthritis.Arthritis Res Ther,2003,5:R210-213.
  • 8Vallejo AN,Weyand CM,Goronzy JJ.Functional disruption of the CD28 gene transcriptional initiator in senescent T cells.J Biol Chem,2001,276:2565-2570.
  • 9Bryl E,Vallejo AN,Weyand CM,et al.Down-Regulation of CD28 expression by TNF-alpha.J Immunol,2001,167:3231-3238.
  • 10Warrington KJ,Takemura S,Goronzy JJ,et al.CD4+CD28-T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems.Arthritis Rheum,2001,44:13-20.

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中国药物与临床
2009年 第8期

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