老年心绞痛患者血清脂联素、抵抗素与C-反应蛋白的变化分析

The analysis of serum level change of adiponetin,resistin and CRP in old patients with UAP

目的:探讨不稳定型心绞痛(UAP)患者血清脂联素、抵抗素与C-反应蛋白(CRP)水平在治疗前后的变化及在动脉粥样硬化发展中的病理生理意义。方法:选取25例UAP(UAP组)患者和20例正常人(对照组),分别检测UAP组治疗前后及对照组血清脂联素、抵抗素、CRP水平,并进行比较。结果:UAP组治疗前血清抵抗素、CRP水平高于对照组(P<0.05),脂联素水平低于对照组(P<0.05),血清脂联素水平与抵抗素、CRP水平呈负相关,抵抗素水平与CRP水平呈正相关。UAP组治疗后抵抗素和CRP水平下降,脂联素水平升高(P<0.05)。结论:脂联素和抵抗素是冠状动脉疾病的独立危险因素,将冠心病与内分泌密切联系在一起。CRP是敏感的炎症指标,具有促炎效应,参与AS的致病过程。三者可能共同促进了AS的发展。

Objective： To evaluate the changes of the serum level of adiponetin, resistin and CRP in old patients with unstable angina pectoris （UAP） before and after the therapy and their possible significant in the devolopment of AS. Methods： 25 cases of UAP （UAP group） and 20 normal people （control group） were selected as our subjects. Serum level of diponetin, resistin and CRP of the UAP group before and after treatment and those of control group were measured and compared. Results： The serum level of CRP and resistin of UAP group was higher than that of control group （P〈0.05）, hut the serum level of adponetin of UAP group before treatment was lower than that of control group （P〈0.05）. The serum level of adiponetin was negatively correlated with resistin and CRP, but the serum level of resistin was positively correlated with CRP. After the treatment, the serum level of resistin and CRP was decreased, and the level of adiponetin was increased （P〈0.05）. Conclusion： Adiponectin and resistin may be independent risk factors of coronary artery diseases, and they connect the coronary heart diseases with endocrtin tightly. CRP is a sensitive inflammtory marker, it has a remarkble effect to the inflammtory and participates in the devolopment of AS. They may together promote the development of AS.