大黄免煎颗粒组方对急性重症胰腺炎患者胃动素和胃泌素水平的影响

Influence of Dahuang Granule Prescription on the Level of Motilin in Plasma and Gastrin in Serum of Patients with Severe Acute Pancreatitis

目的观察大黄免煎颗粒组方对急性重症胰腺炎(SAP)患者血浆胃动素、血清胃泌素水平的影响。方法将严格按标准选入的64例患者分为治疗组(32例)和对照组(32例),分别采用大黄免煎颗粒和常规疗法治疗,并于治疗前后以放射免疫分析法测定血浆胃动素、血清胃泌素水平。结果治疗组于治疗1周后胃动素、胃泌素水平变化最为显著,与对照组比较,胃动素水平明显升高(P<0.05),而胃泌素水平下降(P<0.01)。结论大黄免煎颗粒能够使SAP患者血中胃动素水平升高,胃泌素水平下降。

Objective To study the influence of Dahuang granule on the level of motilin in plasma and gastrin in serum of patients with severe acute pancreatitis （SAP）. Methods Sixty-four patients with SAP were divided into Dahuang granule group （32 cases） and control group （32 cases）, treated with Dahuang granule and routine therapy respectively. The level of motilin in plasma and gastrin in serum of the two groups were detected by radioimmunoassay method. Results After treated for one week, the level of mo^in in Dahuang granule group was significantly higher than that in the control group （P 〈0.05）, and the level of gastrin was significantly lower than that in the control group （P 〈0.01）. Conclusion Dahuang granule can increase motilin and decrease gastrin of patients with SAP.