摘要
目的探讨经阴道多普勒超声对卵巢恶性肿瘤血管生成的预测价值。方法29例浆液性卵巢癌患者于手术前行经阴道彩色多普勒超声(TV-CDU)检查测定搏动指数(PI值)、阻力指数(RI值)及血管点指数(VPI值),记录详细的临床病理参数,并用免疫组织化学方法测定肿瘤组织中的微血管密度(MVD)值。结果PI值在各组间差异无统计学意义;RI值在淋巴结转移组显著低于未转移组,差异有统计学意义;而VPI在FIGO分期较晚期及有淋巴结转移组显著高于其相应对照组,差异有统计学意义,且与MVD值呈正相关关系。结论术前TV-CDU检测对卵巢恶性肿瘤的血管生成有一定的预测价值,VPI可能是—个较好的预测指标。
Objective To investigate the preoperative predictive value of angiogenesis by transvaginal color Doppler ultrasound （TV-CDU） in ovarian serous adenocarcinoma. Methods Twenty-nine patients were examined by TV-CDU to detect several color Doppler features, PI, RI and VPI, Clinical and pathologic data were recorded, and the MVD of the excised tumor was assessed immunohistochemically. Results There was no significant value of PI between every controlled groups; there was significantly higher RI in lymph node metastasis group than in nonlymph node metastasis group; there was significantly higher VPI in advanced stage group and lymph node metastasis group than that in low-stage and nonlymph node metastases group respectively. There was a significant correlation between VPI and MVD. Conclusion Preoperative examination of TV-CDU in ovarian serous adenocarcinoma provides encouraging predictability and VPI coqld be a useful parameter for preoperative assessment of tumor angiogenesis.
关键词
卵巢肿瘤
超声检查
多普勒
彩色
血管生成
Ovarian neoplasms Ultrasonography, Doppler, color Angiogenesis
