摘要
目的研究大黄对创伤失血性休克(T/HS)患者肠功能障碍患者的治疗作用。方法T/HS肠功能障碍98例,随机分成两组:治疗组(45例),应用生大黄10 g,每日2次胃管注入;对照组(53例)除不应用生大黄外,原发病及其他治疗与治疗组一致。观察两组患者肠功能障碍的恢复率、恢复时间及多器官功能障碍综合征(MODS)的发生率、病死率等。结果治疗组的肠功能障碍恢复率高于对照组(82%和36%),肠功能障碍的持续时间低于对照组[(1.5±1.2)d,(5.8±3.0)d],MODS发生率低于对照组(27%和70%),两组比较差异具有统计学意义(P<0.05)。MODS的病死率分别为17%和29%,治疗组病死率低于对照组,两组比较差异无统计学意义。结论大黄对T/HS患者肠功能障碍具有较好的治疗作用,可以明显降低MODS的发生率和病死率。
Objective To study the effects of rhubarb on gut dysfunction of trauma/hemorrhagic shock（T/HS） patients. Methods Ninety-eight patients with T/HS gut dysfunction were divided into 2 groups randomly： the treat ment group （n=45）, treated with rhubarb, and the control group （n=53）, the therapy unnnimous with treat group excluding treat with rhubarb. The alteviative rate and time of gut dysfunction,morbidity and mortality of MODS in 2 groups were observed. Results In the treat ment group, the alleviative rate of gut dysfunction was higher than that of the control group （82%vs36%）; the continuance of gut dysfunction was shorter than that of the control group [（1.5±1.2）d. vs （5.8±3.0）d]; the morbidity of MODS was lower than tnat of the control group （270//00 vs 700/00）. There was statistical difference between two groups （P〈0.05）. The mortality of MODS in treat merit group was lower than that of the control group （17%vs 29%）, though there were no statistical differences between two groups, the mortality of treat group was lower than that of the control group. Conclusion Rhubarb has the therapeutic effect on gut dysfunction of T/HS and reduces the morbidity and mnrtalitv of MODS.
