血清及腹水CA199、CA125水平在肝硬化患者中的临床意义

Role of CA199,CA125 levles of serum and ascites in liver cirrhosis

目的:探讨血清及腹水CA199、CA125水平在肝硬化患者中的临床意义。方法:肝硬化组91例,其中肝硬化无腹水患者50例,肝硬化伴腹水患者41例;正常对照组30例。检测血清CA199、CA125,肝硬化伴腹水患者同时检测血清及腹水CA199、CA125,并作相关性分析。结果:两组肝硬化患者血清CA199、CA125浓度均明显高于正常对照组。肝硬化伴腹水患者血清CA199、CA125水平显著高于肝硬化无腹水患者(P<0.01);血清CA199、CA125的水平随病情好转而下降。结论:肝硬化患者血清CA199、CA125升高水平与腹水的存在有关,作为肝硬化腹水的监测指标有一定的临床意义。

Objective： To investigate the clinical significance of CA199 ,CA125 levels of serum and ascites in hepatic cirrhosis. Methods： Ninety-one patients with liver cirrhosis were divided into two groups （group A, n = 50 ;group B, n = 41 ） according to existence of ascites and 30 health subjects were enrolled as control （group C）, patients in group B with ascites underwent determination of CA199, CA125 levies of serum and ascites; patients in group A without ascites and group C underwent determination of CA199, CA125 levles of serum, and analysis of relation between CA199, CA125 and ascites was done. Results： Serum CA199,CA125 levels of patients in group B and A were significant higher than that in group C; serum CA199 ,CA125 levels of patients in group B were significant higher than that in group A （P 〈 0.01 ） ; serum CA199, CA125 levels decreased with the improving of disease. Conclusion： Elevated serum CA199, CA125 levels of patients with cirrhosis relates to ascites, which may be a parameter for the monitoring of ascites.