冷沉淀与凝血酶原复合物联合在大出血中的应用

Application of combination of cryoprecipitate and prothrombin complex concentrate for hemorrhage

目的:通过冷沉淀(CRYO)与凝血酶原复合物(PCC)联合和单独使用在大出血中疗效比较,探讨成分输血在创伤性失血中的联合应用。方法:对照组分别输注CRYO、PCC,观察组联合输注CRYO+PCC。测定两组输注前1h和输注后2～5h相关指标,活化部分凝活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)变化情况。结果:观察组比对照组APTT、TT、PT明显缩短,FIB显著升高,差别有显著性意义(P<0.01)。结论:联合应用冷沉淀与凝血酶原复合物在创伤性失血患者治疗中,联合输注组比单独输注组疗效更显著。

Objective： To compare the effect of combination of cryoprecipitate （CRYO） and prothrombin complex concentrate （PCC） in the treatment of hemorrhage. Methods： Patients with traumatic bleeding undergoing blood transfusion were divided randomly into group A and B, patients in group A were infused with CRYO and PCC respectively, and patients in group B were infused with CRYO ＋ PCC; related parameters were determined 1 h before and 2 - 5 h after infusion, including activated partial thrombin time （APTr）, thrombin time （TT）, prothrombin time （PT） and fibrinogen （FIB）, and the results were studied. Results： Comparing group A with group B, APTT, TTand PT was significant shorter and FIB was significant higher in group B than group A （ P 〈 0. 01 ）. Conclusion ： Combination of cryoprecipitate and prothrombin complex concentrate for traumatic hemorrhage has better effects than cryoprecipitate or prothrombin complex concentrate alone.