盐酸氨溴索联合654-2佐治毛细气管炎的疗效观察

Curativ Effect Observation of Ambroxol Hydrochloride Combined with 654-2 in Treatment with Capillary Tracheitis

目的观察盐酸氨溴索联合654-2佐治毛细气管炎的临床疗效。方法2008年1月至2009年1月,136例毛细气管炎患儿随机分为对照组和治疗组,每组68例,对照组采用综合治疗,治疗组在此基础上加用盐酸氨溴索和654-2治疗。结果治疗组的治愈率明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗组咳嗽消失、喘憋消失、肺部体征消散及住院时间明显短于对照组,两组比较差异有统计学意义(P<0.05)。治疗组治疗后呼吸、心率、PaO2及PaCO2与治疗前比较,差异有统计学意义(P<0.05);治疗组治疗后呼吸、心率、PaO2及PaCO2均较同期对照组明显改善,两组比较差异有统计学意义(P<0.05)。而对照组治疗前后呼吸、心率、PaO2及PaCO2比较,差异无统计学意义(P>0.05)。结论盐酸氨溴索联合654-2佐治毛细气管炎具有良好的协同作用,效果明显。

OBJECTIVE To observe the clinical effects of ambroxol hydrochloride combined with 654-2 in treatment with capillary tracheitis. METHOD From January 2008 to January 2009, 136 cases of capillary tracheitis children were randomly classified into two groups, which control group with 68 cases were treated with composite treatment and treatment group with 68 cases were treated with ambroxol hydroehloride combined with 654-2. RESULTS The cure rates in treatment group were significantly higher than those in control group（P〈0.05 ）. The disappearing time of cough, wheezy, bellows objective sign and admission duration in treatment group were shorter than in control group（P〈0.05 ）. There was a significant difference in breath rate, heart rate PaO2 and PaCO2 of treatment group between pre-treatment and after-treatment（P〈0.05 ）. Moreover, after treatment the breath rate, heart rate PaO2 and PaCO2 in treatment group were significantly improved than those in control group（P〈0.05 ）. There was no significant difference in breath rate, heart rate PaO2 and PaCO2 of control group between pre-treatment and after-treatment（P〉0.05 ）. CONCLUSIONS The ambroxol hydroehloride combined with 654-2 in treatment with capillary tracheitis has synergistic reaction, good effects, which is worthy to extending.