凌晨血压升高与血栓前状态关系分析

Morning blood pressure surge and prothrombotic state

目的探讨原发性高血压(EH)患者凌晨血压增高与血栓前状态(PTS)的关系。方法使用酶联免疫法(ELISA)和凝固法测量160例EH患者外周血浆Ⅷ相关抗原(vWF:Ag)、血小板α颗粒膜蛋白-140(GMP-140)、D-二聚体(D-dimer)和纤维蛋白原(Fg)的水平,并行动态血压监测。根据动态血压结果,有44例凌晨血压增高(MBPS组),160例非凌晨血压增高(NMBPS组),对两组患者上述指标进行比较。结果MBPS组上述指标较NMBPS组显著升高,差异有统计学意义(P<0.05)。结论EH组人群凌晨血压增高进一步促进血栓前状态发生。

Objective To investigate the relationship between morning blood pressure surge and prothrombotic state in essential hypertension（EH） patients. Methods One hundred and sixty EH patients were categorized by the level of morning blood pressure surge：morning blood pressure surge（MBPS） group（n=44）,nonmorning blood pressure surge（NMBPS） group（n=116）. Levels of vonwillebrand factor antigen（vWF ： Ag）, platelet alpha granule membrane protein 140 （GMP 140）, fibrin D-dimer （D-dimer） and fibrinogen（Fg） were measured in peripheral plasma from two groups using ELISA. Results Compared with NMBPS group,the plasma levels of vWFAg,GMP-140,d-Dimer and Fg in MBPS group were increased signifieantly（P〈0.05）. Conclusion Morning blood pressure surge is closely related with prothombotic state.