摘要
目的探讨胰岛素样生长因-子1(insulin-like growth factor-1,IGF-1)与脑胶质瘤发生的关系。方法67例脑胶质瘤患者按病理分级标准分为高级别组和低级别组,以30例健康人作为对照组。比较正常人及胶质瘤患者手术前后血清IGF-1含量。结果高级别组脑胶质瘤患者血清中IGF-1水平显著高于低级别组IGF-1水平,且均显著高于正常人;脑胶质瘤患者手术后血清IGF-1水平较手术前显著下降。结论脑胶质瘤患者血清IGF-1表达水平可以反映肿瘤恶性程度及治疗预后。
Objective To investigate the relationship between IGF-1 and gliomas. Methods Sixty-seven cases with gliomas and 30 healthy persons were enrolled in this study. According to pathological diagnosis, all patients were divided into high-grade group and low-grade group. Healthy persons were control group. Serum IGF-1 level of all persons was measured and compared among three groups. Results Level of IGF1 in high-grade group differed significantly from those in low-grade group and control group. Level of IGF-1 decreased significantly after tumorectomy. Conclusion The level of IGF1 in the patients with glioma plays an im- portant role in its pathologic types and prognosis.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第15期1941-1942,共2页
Chongqing medicine
