超体质量及肥胖儿童低度炎性反应与胰岛素抵抗的研究进展

Study Progress of Low-Grade Inflammation in Pathogenesis of Children with Obesity and Insulin Resistance

肥胖已成为危害全球儿童青少年健康的重要疾病之一,胰岛素抵抗是肥胖及其相关并发症的核心环节,其发生机制不清楚,近年来炎性反应病因学理论倍受关注。脂肪组织源性促炎性因子的释放、脂肪组织局部单核-巨噬细胞系统、氧化应激等与肥胖儿童低度炎性反应的启动有关。针对炎性因子在肥胖及胰岛素抵抗病理生理中的作用的研究,将为肥胖及其并发症的防治提供新的思路。

Obesity has been a world -wide growing health problem in children and adolescents,insulin resistance plays a pivotal role in the pathogenesis of obesity - associated complications, the mechanism is still unknown. There is growing evidence that obesity is associated with low - grade inflammation in youth. The onset of low - grade inflammation in obesity may be associated with the inflammatory cytokine secreted by adipose tissue,local Monocyte/ Macrophage system and role of oxidative stress. The study of inflammatory cytokines in pathogenesis of obesity and insulin resistance will help to develop new treatment strategies to prevent obesity and obesity - associated complications.