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与肿瘤侵袭转移相关的微小RNA研究进展

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摘要 微小RNA(microRNA)是一类全长为19~25nt的非编码单链小分子RNA,通过与靶基因3’端非翻译区(3’UTR)结合,降解mRNA或抑制其翻译,从而调控靶基因的表达。从1993年Lee等拉0发现lin-4的小RNA,并命名为微小RNA以来,目前已发现500多种微小RNA作用于人体内,它们与细胞周期的调控、细胞分化和凋亡有密切联系。
作者 郑珉 梁新华
出处 《中华口腔医学杂志》 CAS CSCD 北大核心 2009年第8期508-510,共3页 Chinese Journal of Stomatology
基金 国家自然科学基金(30872889)
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