脑出血患者精氨酸加压素与水代谢相关性研究

Relationship between water-electrolyte metabolism and the changes of plasma arginine vasopressin in patients with hypertensive intracerebral hemorrhage

目的探讨高血压脑出血患者血中精氨酸加压素(AVP)含量的改变与病情、病程之间的关系,以及此量变与水代谢紊乱的相关性。方法以高血压脑出血患者为研究对象,定时定量采血。采用放射免疫法测量血中AVP浓度。精确计算出入量。动态监测电解质,以及生命体征。结果高血压脑出血患者急性期血中AVP含量显著升高。峰值位于发病后第一个24h,后逐渐降低,持续到发病第9d仍较健康对照值高。所有患者均未出现严重的水代谢紊乱。结论高血压脑出血患者血中AVP含量升高程度与出血量、病程、病情、出血部位有密切的关系。并且一定程度的升高不会引起水代谢紊乱。

Objective To study the relationship between the changes of plasma arginine-vasopressin （AVP）, type and duration of the illness and water-electrolyte metabolism in patients with hypertensive intraeerebral hemorrhage. Methods Blood samples of patients with hypertensive intracerebral hemorrhage were obtained in time for the measurement of AVP by radioimmunoassay. Fluid intake and output were recorded accurately. Vital signs were monitored and electrolytes were detected in periodic time. Results The plasma levels of AVP of the patients increased and reached a peak within 24 h after hypertensive intracerebral hemorrhage and then they decreased after that time, which was higher than that of normal controls from 24 h to 9 d. But no patients presented water-elec.trolyte disorder. Conclusion The increase of AVP levels in patients with hypertensive intraeerebral hemorrhage closely correlated with the volume of hemorrhage, the process of illness and the site of hemorrhage. The increase of the AVP level in certain range does not result in water-electrolyte disorder.