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CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展 被引量：2

Advance in the research of the mechanism of CXCL12/ CXCR4 axis induced osseous metastasis of prostate cancer
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摘要 研究发现趋化因子CXCL12(Stromal-derived factor-1,SDF-1)和受体CXCR4[chemokine(C-X-Cmotif)receptor4]广泛表达于组织和器官上,相关的研究发现其与前列腺癌细胞的黏附、侵袭、增殖和生存有关,并认为其在前列腺癌骨转移的发生中发挥重要作用。通过阐明CXCL12/CXCR4生物学轴和前列腺癌骨转移之间的关系,从而寻找有助于疾病治疗的新途径。 CXCL12 （ stromal - derived factor - 1, SDF - 1 ） and its receptor CXCR4 （ chemokine （ C - X - C motif） receptor 4） were demonstrated to be widely expressed in a broad array of tissues and organs. Recent studies suggested that CXCL12/CXCR4 axis was related to the adhesion, invasion, proliferation and survival of prostate cancer cells, and played an important role in bone metastasis. Elucidating the relationship between the CXCL12/CXCR4 axis and the development of bone lesion of prostate cancer is helpful to find a new way to treat the disease.
作者 杨晨 姚阳
机构地区 上海市交通大学附属第六人民医院肿瘤内科
出处 《现代肿瘤医学》 CAS 2009年第8期1599-1601,共3页 Journal of Modern Oncology
基金 上海市市级医学慢性病综合防治项目资助(SHDC12007304)
关键词 CXCL12 CXCR4 前列腺癌 骨转移 CXCL12 CXCR4 Prostate cancer Bone metastasis
分类号 R737.25 [医药卫生—肿瘤]
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参考文献19

  • 1Yu L,Cecil J,Peng S B,et al.Identification and expression of novel isoforms of human stromal cell-derived factor 1[J].Gene,2006,374:174-179.
  • 2Jennifer M,Burns,Bretton C,et al.A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival,cell adhesion,and tumor development[J].Exp Med,2006,203:2201-2213.
  • 3Charnaux N,Brule S,Hamon M C,et al.Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/CXCL12[J].FASEB J,2005,272(8):1937-1951.
  • 4Balkwill F.Cancer and the chemokine network[J].Nat Rev Cancer,2004,4(7):540-550.
  • 5Sun Y-X,Wang J,Shelburne CE,et al.The expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo[J].J Cell Biochem,2003,89(3):462-473.
  • 6Aiuti A,Webb IJ,Bleul C,et al.The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechani sm to explain the mobilization of CD34+ progenitors to peripheral blood[J].J Exp Med,1997,185(1):111-120.
  • 7Weiss L,Orr FW,Honn KV.Interactions of cancer cells with the microvasculature during metastasis[J].FASEB J,1988,2(1):12-21.
  • 8Engl T,Relja B,Marian D,et al.CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins[J].Neoplasia,2006,8(4):290-301.
  • 9Sun Y-X,Fang M,Wang JH,et al.Expression and activation of αvβ integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells[J].Prostate,2007,67(1):61-73.
  • 10Havens AM,Jung Y,Sun Y-X,et al.The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis[J].BMC Cancer,2006,6(1):195.

同被引文献10

  • 1Porcile C, Bajetto A, Barbieri F, et al. Stromal ceil-derived factor-1 alpha(SDF-1 alpha/CXCL 12) stimulates ovarian cancer cell growth through the EGF receptor transactivation[J]. Exp Cell Res, 2005, 308: 241-253.
  • 2Tanaka T, BaiZ, Srinoul prasert Y, etal. Chemokines in tumor progression and metastasis[J]. Cancer Science, 2005, 96 (6) 317-322.
  • 3Abraham RS, Ballman KV, DispenzieriA, et al. Functional gene expression analysis of clonalplasma ceils identifies a unique molecular profile for light chain amyloidosis[J]. Blood, 2005, 105(2) : 794-803.
  • 4Smith JR, Falkenhagen KM, Coupland SE, et al. Malignant B cells from patients with primary central nervous system Iymphoma express stromal cell-derived factor-1 [J]. Am J Clin Pathol, 2007, 127(4): 633-641.
  • 5Alsayed Y, Ngo H, Runnels J, et al. Mechanisms of regulation of CXCR4/SDF-1(CXCL12) dependent migration and homing in multiple myeloma [J]. Blood, 2007, 109(7) : 2708-2717.
  • 6Kryczek I, Wei S, Kelier E,et al. The chemokine stroma-derived factor (SDF-1 /CXCLI2) plays multiple roles in tumor pathogenesis [J]. Am J Physiol Cell Physiol, 2007, 292(3) : 087-995.
  • 7Kryczek I, Lange A, Mottram P, et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers[J]. CancerRes, 2005, 65: 465-472.
  • 8B.-S. Youn,K.-Y. Yu,J. Oh,J. Lee,T.-H. Lee,H. E. Broxmeyer. Role of the CC Chemokine receptor 9/TECK interaction in apoptosis[J] 2002,APOPTOSIS(3):271～276
  • 9沈晓燕,王绍海,梁铭霖,汪宏波,肖兰,王泽华.CXCR4及其配体SDF-1在宫颈癌转移中的作用及其机制研究[J].癌症,2008,27(10):1044-1049. 被引量：18
  • 10吴继,白冰,徐振晔,赵晓珍,许能.CXCR4-CXCL12轴在肺癌中的表达及临床意义[J].实用中西医结合临床,2008,8(5):1-2. 被引量：2

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现代肿瘤医学
2009年 第8期

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