不同部位瘢痕疙瘩组织中IGF-I、IGF-IR的表达及其意义

Expression and significance of IGF-I and IGF-IR in different part of keloid

目的通过分析瘢痕疙瘩周围部和中央部组织中IGF—I、IGF—IR表达的差异，探讨瘢痕疙瘩呈浸润性生长的机制。方法收集手术切除的瘢痕疙瘩组织8例及周围正常皮肤组织4例，对不同部位的瘢痕疙瘩组织和正常皮肤组织进行免疫组织化学染色，观察各组中IGF—I、IGF—IR的表达，比较瘢痕疙瘩不同部位和正常皮肤组织中IGF—I．IGF—IR表达的差异。结果正常皮肤组织中成纤维细胞中IGF—I,IGF—IR的表达均呈阴性。瘢痕疙瘩周围组织成纤维细胞中IGF—I的表达明显高于中央部，差异有统计学意义（P〈0．05）；瘢痕疙瘩周围部组织纤维细胞中IGF—IR明显高于中央部，差异有统计学意义（P〈0．05）。结论瘢痕疙瘩不同部位IGF—I、IGF—IR的表达差异可能是导致瘢痕疙瘩呈浸润性生长的机制之一。

Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin - like growth factor - I （ IGF - I ） and the insulin - like growth factor - I receptor （ IGF - IR） index. Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF - I and IGF - IR. IGF - I and IGF - IR index of difference parts in keloids and normal skin were compared. Results These were no positive fibroblasts in normal skin samples. The IGF - I and IGF - IR index of peripheral parts of keloids are higher than those of central parts, and there is significant difference （ P 〈 0. 05）. Conclusion The difference in distribution of IGF - I and IGF - IR index may be responsible for the aggressive growth of keloid.