精神分裂症伴发代谢综合征患者下肢动脉的彩超研究

Color Doppler ultrasound study on pathological changes of lower extremity arteries in schizophrenics patients with metabolic syndrome

目的探讨精神分裂症伴发代谢综合征患者的下肢动脉病变情况。方法应用彩色多普勒超声对50例精神分裂症伴发代谢综合征患者下肢动脉进行检查,并与30例健康志愿者对照,测量血管内径、收缩期最大流速、内中膜厚度、斑块大小及数目。结果50例中,内中膜增厚大于1.1mm者41例,有粥样斑块并引起不同程度狭窄者33例。股总动脉、股浅动脉、足背动脉的内膜明显厚于对照组(P<0.01或P<0.05),斑块数明显多于对照组(P<0.01)。结论精神分裂症伴发代谢综合征患者下肢动脉发生了程度不等的病变,用彩色多普勒超声检测能明确精神分裂症伴发代谢综合征患者下肢动脉病变的部位和程度,对临床具有指导意义。

Objective To explore the pathological changes of lower extremity arteries of schizophrenics patients with metabolic syndrome. Methods Fifty schizophrenics patients with metabolic syndrome（MS） and 30 normal volunteers were included in this study. The inner diameters, peak systolic velocities and intimamedia thicknesses of the lower extremity arteries, and the sizes and numbers of the plaques in the lower extremity arteries were obtained with color Doppler ultrasound（CDU）. Results In the fifty schizophrenics patients with metabolic syndrome, the intimamedia thicknesses of forty one were thicker than 1.1 mm and thirty three had plaques which had brought stenosis in different degrees. The intimamedia thicknesses of the common femoral, popliteal and posterior tibial arteries in the schizophrenics patients with metabolic syndrome were significantly thicker than those in the normal volunteers（ P 〈0.01 or P （0.05） ,and a greater number of plaques in the lower extremity arteries were observed in the patients, as compared with the normal volunteers（ P 〈 0.01 ）. ConclusionVarious pathological changes had taken place in the lower extremity arteries of the schizophrenics patients with metabolic syndrome. The sites and degrees of the lower extremity arterial pathological changes in schizophrenics patients with metabolic syndrome can be definitely detected with CDU.