宫颈癌放疗前应用双氧水阴道冲洗的近期疗效观察

CURATIVE EFFECTS OF HYDROGEN PEROXIDE VAGINAL WASH ON CERVICAL CANCER BEFORE RADIOTHERAPY

目的观察双氧水在宫颈癌放疗前应用的临床效果。方法将2005年3月~2007年3月在我院行根治性放疗的120例中晚期宫颈癌患者随机分为两组。研究组60例,放疗前常规应用双氧水阴道冲洗;对照组60例,放疗前常规应用新洁尔灭液冲洗。两组患者放射治疗方案相同。比较两组患者局部肿瘤消退情况、治疗效果及并发症发生情况。结果宫颈局部肿瘤缩小50%与100%的肿瘤放射剂量：研究组分别为（20.64±5.03）Gy（、33.09±7.86）Gy;对照组分别为（42.05±14.06）Gy、（50.08±21.02）Gy。肿瘤完全消退时间：研究组为（31.26±10.25）d,对照组为（42.80±9.06）d,两组比较差异有显著性（P〈0.01）。近期有效率、局部复发率、远处转移率及放射性不良反应发生率两组比较差异均无显著性（P〉0.05）。结论宫颈癌患者放疗前常规应用双氧水阴道冲洗能加快肿瘤消退,能否减少放射剂量及是否提高远期疗效有待进一步观察。

Objective To observe the clinical effects of hydrogen peroxide vaginal wash on cervical cancer.Methods 120 cases of cervial cancer at the middle and late stages received radical treatments from March,2005 to March,2007 and were randomly divided into the reseaeh group of 60 cases treated with hydrogen peroxide vaginal wash and the contrast group of 60 cases treated with bromogeramine liquid, radiotherapy used in both groups. The local tumor regression,curative effects and complications in the two groups were compared. Results The radiation doses to reduce the size of local tumor to 50% and 100% were（20.64±5.03）Gy and（33.09 ± 7.86）Gy in the research group and（42.05 ± 14.06）Gy and（50.08 ± 21.02）Gy in the contrast group respectively. The time of complete regression of tumor was（31.26 ± 10.25）days in the research group and（42.80 ± 9.06） days in the contrast group respectively （ P 〈 0.01 ）. No significant differences were found in both groups in terms of recent effects, local replsae incidence, distant metastases and side effects （P 〉 0.05 ）. Conclusion Hydrogen peroxide vaginal wash can be used to promote the regression of tumor, but the effects of the dose of radiotherapy remains to be observed.