芬太尼复合喷他佐辛术后镇痛对妇科患者免疫功能的影响

THE EFFECTS OF POSTOPERATIVE ANALGESIA WITH FENTANYL AND PENTAZOCINE ON THE IMMUNITY OF GYNECOLOGICAL PATIENTS

目的观察芬太尼复合喷他佐辛用于妇科患者术后静脉自控镇痛的效果及其对免疫功能的影响。方法将120例妇科患者随机分为两组,观察组应用芬太尼复合喷他佐辛术后镇痛,对照组应用芬太尼。观察两组患者视觉模拟评分(VAS评分)及不良反应,测定其血浆IL-6I、L-10含量。结果两组患者各时点VAS评分无统计学意义(P>0.05)。对照组术后不良反应发生率为60%,高于观察组的15%(χ2=4.66,P<0.05);两组患者血浆IL-6在术毕、术后244、8 h均有统计学意义,对照组均高于观察组;两组患者血浆IL-10在术后244、8 h均有统计学意义,对照组均低于观察组。结论芬太尼复合喷他佐辛应用于妇科患者术后镇痛效果明显,对免疫功能影响较小。

Objective To observe the effects of postoperative patient-controlled epidural analgesia on the immunity of gynecological patients. Methods 120 cases of gynecological patients were randomly divided into the observation group treated with fentanyl and pentazocine and the contrast group treated with fentanyl. Both groups were evaluated by visual analogue scale（VAS） and the contents of plasmaIL-6 and IL-10 were determined. Results Nosignificant differences were found between the two groups according to VAS（ P 〉0.05）. The incidences of side effects inthe contrast group and the observation group were 60 % and 15 % （X^2 = 4.66, P 〈 0.05）respectively. The content of plasma IL-6 was found significantly higher but the content of plasma IL-10 was much lower in the contrast group than in the observation group when determined 24 hours and 48 hours after the operations. Conclusion The combined use of fentanyl and pentazocine can produce good curative effects and has little effect on immunity.