2型糖尿病患者肺功能改变及影响因素研究

Changes of pulmonary function in patients with type 2 diabetes and the influence factors

目的检测2型糖尿病患者的肺功能,探讨肺是否为糖尿病病变的靶器官。方法检测120例2型糖尿病患者和40例健康者的肺通气功能、弥散功能以及糖化血红蛋白(HbA1c)并进行比较,40例有并发症糖尿病患者给予胰岛素强化治疗4周后再次检测以了解治疗前后的肺功能变化。结果2型糖尿病组患者肺通气功能及弥散功能均较正常对照组明显降低(P<0.05),有并发症组肺通气功能及弥散功能较无并发症组明显降低(P<0.05),治疗后患者的一氧化碳弥散量(DLCO)及HbA1c较治疗前有所好转,并与变化相关。结论2型糖尿病患者肺功能受损,肺脏是糖尿病病变的靶器官之一,控制血糖是防治糖尿病患者肺功能损害的重要措施。

Objective To explore whether lung is a target organ of pathologic changes in diabetes by evaluate the pulmonary function in the patients with type 2 diabetes. Methods Pulmonary function and glycesylated hemoglobin Al c （ HBAl c） were investigated in 120 patients with type 2 diabetes and 40 healthy subjects. 40 patients of type 2 diabetes with complications were given 4 weeks intensive insulin therapy,pulmonary function and HBAlc were investigated again. Results The pulmonary ventilation function and diffusion capacity in type 2 diabetes group were lower than the control group（ P 〈0.05 ）, The pulmonary ventilation function and diffusion capacity in type 2 diabetes with complications group were lower than that non-complications group（ P 〈 0.05 ）. After 4 weeks intensive insulin therapy, diffusion capacity of carbonmonoxide （DLCO） and HBAl c improved and related to the changes. Conclusion The pulmonary function in patients with type 2 diabetes is impaired and lung may be the target organ of pathologic changes of diabetes. Blood sugar control is important for the prevention and cure for pulmonary function impaired.